15:00 - 16:00 (UTC), Thursday 3 March 2022

TYC Seminar: Interpreting experiments using simulations and using experiments to improve simulations of intrinsically-disordered proteins - Kresten Lindorff-Larsen, University of Copenhagen

Intrinsically disordered proteins (IDPs) and flexible regions in multi-domain proteins display substantial conformational heterogeneity. Characterizing the conformational ensembles of these proteins in solution typically requires combining data from one or more biophysical techniques with computational modelling or simulations [1,2]. Experimental data can either be used to assess the accuracy of a computational model or to refine the computational model to get a better agreement with the experimental data. I will discuss two different approaches to integrate experiments and simulations of IDPs.

Kresten Lindorff-Larsen’s current research interests include developing and applying computational methods for integrative structural biology, and the integration of biophysics and genomics research.

https://ucl.zoom.us/j/93351179800?pwd=bVBhNjJhZURNc05wR1piTUtTWXBVUT09

Meeting ID: 933 5117 9800 Passcode: TYCIGS

https://thomasyoungcentre.org/event/tyc-seminar-interpreting-experiments-using-simulations-and-using-experiments-to-improve-simulations-of-intrinsically-disordered-proteins/

14:00 - 17:00 (UTC), Wednesday 30 March 2022
XLG1 Lecture Theatre, Christopher Ingold Building
20 Gordon Street
London,WC1H 0AJ, United Kingdom

TYC Distinguished Speaker Symposium: Modelling Surfaces & Catalysis

Professor Joachim Sauer – Humboldt University of Berlin

Professor Adrian Mulholland – University of Bristol
Developments in biocatalysis

Dr Thomas Keal – Science and Technology Facilities Council (STFC)

Dr Edina Rosta – University College London
Dynamics, function and mechanism of phosphate processing enzymes

https://ucl.zoom.us/j/96861596259?pwd=U1pRK3V3UlVoTm5XMW5qWHNKc1BJdz09
Meeting ID: 968 6159 6259
Passcode: TYCSymp

https://thomasyoungcentre.org/event/tyc-distinguished-speaker-symposium-modelling-surfaces-catalysis/

The Thomas Young Centre remains a renowned London-based interdisciplinary research network which brings together a range of groups across the capital whose research involves materials and molecular modelling and theoretical chemistry.